{"id":1095039,"date":"2026-02-03T15:57:36","date_gmt":"2026-02-03T14:57:36","guid":{"rendered":"https:\/\/pulse.microsoft.com\/?p=1095039"},"modified":"2026-02-03T15:57:40","modified_gmt":"2026-02-03T14:57:40","slug":"fa2-turning-genomic-data-into-clinical-impact-2","status":"publish","type":"post","link":"https:\/\/pulse.microsoft.com\/da-dk\/transform-da-dk\/healthcare-da-dk\/fa2-turning-genomic-data-into-clinical-impact-2\/","title":{"rendered":"Turning Genomic Data into Clinical Impact"},"content":{"rendered":"<p>When Filippa was seven years old, her family received devastating news: she had a brain tumor. However, alongside fear came hope powered by a shift in how healthcare systems use genomic data. That shift is the foundation of BrainChild, a pioneering initiative working to bring the promise of precision medicine into everyday clinical care.<\/p>\n<p>The BrainChild project, supported by Genomic Medicine Sweden (GMS), aims to bridge research and clinical practices. Per Sikora, who leads the infrastructure efforts at GMS, helps ensure the technology meets the clinical demands.<\/p>\n<blockquote><p>\u201cSweden has a unique opportunity,\u201d says Sikora. \u201cWe\u2019re a relatively small country with a long tradition of quality registries and structured healthcare. If we can get the data foundations right, we can become world leaders in using genomics for diagnostics and treatment.\u201d<\/p><\/blockquote>\n<p><iframe loading=\"lazy\" title=\"Turning Genomic Data into Clinical Impact\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube-nocookie.com\/embed\/vS_ekMLw1w0?feature=oembed&#038;enablejsapi=1&#038;origin=https:%2F%2Fpulse.microsoft.com\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<h2><strong>From Bench to Bedside<\/strong><\/h2>\n<p>For many years, research into genomics and cancer has achieved rapid advances, but integrating those insights into clinical care has been slow. One of the biggest hurdles is data.<\/p>\n<blockquote><p>\u201cIn Sweden today, we do whole-genome sequencing for all children diagnosed with cancer,\u201d says Sikora. \u201cThat\u2019s incredibly valuable, but most of that data is used once for a single patient and then effectively discarded. We don\u2019t yet make use of the full potential of that information.\u201d<\/p><\/blockquote>\n<p>To change that, BrainChild is building an infrastructure that enables large-scale, secure use of genomic and clinical data while maintaining the highest levels of patient privacy. This includes integrating data from sequencing labs with pathology, radiology, and electronic medical records to form a cohesive, structured framework.<\/p>\n<blockquote><p>\u201cWe\u2019re working to build a system where physicians can have a clear, clinically relevant overview,\u201d Sikora explains. \u201cNot just raw data or siloed reports, but insights that support decisions in real time.\u201d<\/p><\/blockquote>\n<h2><strong>The Human Perspective<\/strong><\/h2>\n<p>Filippa\u2019s case provides a powerful example of what this could mean in practice. After sequencing revealed a BRAF V600E mutation\u2014a known driver in some tumors\u2014doctors were able to offer her a targeted therapy instead of traditional chemotherapy. The treatment dramatically reduced the size of the tumor while sparing her many of the side effects of conventional treatment.<\/p>\n<blockquote><p>\u201cBefore, we used to treat these types of tumors with cytostatic drugs, often with poor results,\u201d says Dr. Magnus Sabel, pediatric oncologist at Sahlgrenska University Hospital. \u201cThanks to genomic analysis, we found a targetable mutation and could offer Filippa precision medicine. She avoided many side effects and responded well; her tumor is now 20% of its original size.\u201d<\/p><\/blockquote>\n<p>The success of cases like Filippa\u2019s illustrates the potential of genomic medicine, but it also highlights how far there is to go.<\/p>\n<blockquote><p>\u201cThis is just one example,\u201d says Sikora. \u201cIf we could analyze these kinds of outcomes across hundreds or thousands of cases, we\u2019d be able to identify which treatments work best, for whom, and why. However, for that, we need to be able to access and structure the data.\u201d<\/p><\/blockquote>\n<h2><strong>Building Trust<\/strong><\/h2>\n<p>One of the core principles behind BrainChild is responsible data sharing. \u201cWe need to protect patient privacy while enabling data-driven insights,\u201d Sikora says. \u201cThat\u2019s why we\u2019re working closely with clinicians, researchers, ethicists, and patient organizations to ensure the system we build has trust at its core.\u201d<\/p>\n<p>And time is of the essence.<\/p>\n<blockquote><p>\u201cWe have the technology, the scientific knowledge, and the will, but the clock is ticking. Children are being diagnosed today, and every delay is a missed opportunity to help them.\u201d<\/p><\/blockquote>\n<p>Filippa\u2019s journey offers a glimpse into what\u2019s possible. The goal now is to ensure her story becomes the norm, not the exception.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>When Filippa was seven years old, her family received devastating news: she had a brain tumor. However, alongside fear came hope powered by a shift in how healthcare systems use genomic data. That shift is the foundation of BrainChild, a pioneering initiative working to bring the promise of precision medicine into everyday clinical care. The [&hellip;]<\/p>\n","protected":false},"author":991,"featured_media":1095114,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1803],"class_list":["post-1095039","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-customer-stories-da-dk","specials-transform-da-dk","verticalIndustries-healthcare-da-dk","stories-data-insights-intelligence-da-dk","stories-hvordan-far-jeg-indsigt-fra-mine-data","businessPriorities-data-ai-da-dk"],"_links":{"self":[{"href":"https:\/\/pulse.microsoft.com\/da-dk\/wp-json\/wp\/v2\/posts\/1095039"}],"collection":[{"href":"https:\/\/pulse.microsoft.com\/da-dk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pulse.microsoft.com\/da-dk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pulse.microsoft.com\/da-dk\/wp-json\/wp\/v2\/users\/991"}],"replies":[{"embeddable":true,"href":"https:\/\/pulse.microsoft.com\/da-dk\/wp-json\/wp\/v2\/comments?post=1095039"}],"version-history":[{"count":36,"href":"https:\/\/pulse.microsoft.com\/da-dk\/wp-json\/wp\/v2\/posts\/1095039\/revisions"}],"predecessor-version":[{"id":1095164,"href":"https:\/\/pulse.microsoft.com\/da-dk\/wp-json\/wp\/v2\/posts\/1095039\/revisions\/1095164"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pulse.microsoft.com\/da-dk\/wp-json\/wp\/v2\/media\/1095114"}],"wp:attachment":[{"href":"https:\/\/pulse.microsoft.com\/da-dk\/wp-json\/wp\/v2\/media?parent=1095039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pulse.microsoft.com\/da-dk\/wp-json\/wp\/v2\/categories?post=1095039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}